Results

Bonegapfill

RESULTS 2023


L2.1.1. Morphocompositional and structural characteristics of the composite materials obtained
L2.2.1. Preliminary report on cellular behaviour (cell morphology, viability and proliferation)
L2.3.1. Surface and volume characteristics of composite materials obtained (SEM, contact angle and surface energy, 3D reconstructions)
L2.4.1. Mechanical properties of composite materials obtained (compressive or flexural strength)
L2.5.1. Composite samples for in vitro testing
L2.6.1. Report on the potential of composite materials obtained to contribute to bone formation. Selection of optimal composite materials for increased bioactivity in pre-osteoblast cultures
L2.7.1. Statistical analysis based on experimental results obtained by analysis of composite materials
L2.8.1. Conference presentation and 2 articles submitted for publication in journals indexed by Clarivate Analytics


ACTIVITIES 2023

2.1. Investigation of obtained composite materials
2.2. Short-term in vitro testing of intermediate products
2.3. Complex characterization of surface and volume characteristics of 3D printed products
2.4. Assessment of mechanical characteristics of composite materials
2.5. Preparation of samples for advanced biological investigations
2.6. Advanced in vitro analysis of MC3T3-E1 pre-osteoblastic behaviour
2.7. Statistical analysis of results obtained from the concentration of HA particles and graphene nanoplatelets
2.8. Dissemination of results by participating in international conferences and by submitting for publication two articles.

Articles 2023

Journal research article - ISI Indexed - IF 3,4
Materials, 2023
Selection route of precursor materials in 3D printing composite filament development for biomedical applications.

Authors
Aura-Cătălina Mocanu, Florin Miculescu, Andreea Elena Constantinescu, Ștefan Ioan Voicu, Mădălina-Andreea Pandele, Marian Miculescu, Anisoara Campean, Madalina Negrescu

DOI https://doi.org/10.3390/ma16062359

CNCS - UEFISCDI, project number 583PED financial support is acknowleged


Conferences Oral presentation 2023

Title
The synthesis of PLA/HA composite filaments for biomedical applications

Presented at the
International Conference on Innovative Research, Iasi (Romania)

Date
May 11th to 12th, 2023

CNCS - UEFISCDI, project number 583PED financial support is acknowleged

Invited speaker presentation 2023

Title
Sustainable Technologies for Bone Reconstruction Products and Bioceramic Coatings Development

Presented at the International Conference on Biomaterials and Regenerative Medicine, Bioremed 2023, Sibiu (Romania)

Date
July 19th to 21th, 2023

CNCS - UEFISCDI, project number 583PED financial support is acknowleged

RESULTS 2022


L1.1.1. The current state of information on the subject area
L1.2.1. HA type materials for test samples
L1.3.1. Morpho-compositional and structural characteristics of precursor materials
L1.4.1. Report on the potential biocompatibility of precursor materials
L1.5.1. Mixtures with different proportions of reinforcing materials dispersed in the polymer matrix
L1.6.1. Experimental determination of the behavior of composite materials in aqueous environments
L1.7.1. Samples for the characterization of composite materials
L1.8.1. 3D printed samples of HA reinforced polymers
L1.9.1. Conference presentation and 1 article submitted for publication in journal indexed by Clarivate Analytics


ACTIVITIES 2022

Activity 1.1 Updating information from specialized literature
Activity 1.2 Synthesis of HA of natural origin
Activity 1.3 Morpho-compositional and structural investigation of precursor materials
Activity 1.4 Preliminary evaluation of the in vitro biocompatibility shown by the selected precursor materials
Activity 1.5. One-step addition synthesis of composite and/or reinforced materials
Activity 1.6. Analysis of the behavior in aqueous environments of the obtained composite materials
Activity 1.7. Preparation of samples for the complex evaluation of the characteristics of composite materials
Activity 1.8. Obtaining test samples by 3D printing with filaments from composite materials through the FDM technique
Activity 1.9. Dissemination of results by attending a conference and submitting an article for publication.

Articles 2022

Journal research article - ISI Indexed - IF 4,901
Journal of Functional Biomaterials, 2022
Influence of Ceramic Particles Size and Ratio on Surface—Volume Features of the Naturally Derived HA-Reinforced Filaments for Biomedical Applications.

Authors
Aura-Cătălina Mocanu, Florin Miculescu, Cătălina-Andreea Dasc«lu, Ștefan Ioan Voicu, Mădălina-Andreea Pandele, Robert-Catalin Ciocoiu, Dan Batalu, Sorina Dondea, Valentina Mitran, Lucian-Toma Ciocan

DOI https://doi.org/10.3390/jfb12010013

CNCS - UEFISCDI, project number 583PED financial support is acknowleged


Oral presentation 2022

Title
State-of-the-art of feasible synthesis routes for biogenic composite filaments development for the FDM technology with biomedical applications

Presented at the
9th International Conference “Biomaterials, Tissue Engineering & Medical Devices” BIOMMEDD 2022 in Bucharest (Romania)

Date
July 20th to 24th, 2022

CNCS - UEFISCDI, project number 583PED financial support is acknowleged

Keynote speaker presentation 2022

Title
New fabrication methods for bone regeneration products based on ceramic and composite biomaterials

Presented at the
8th Conference of the Sustainable Solutions for Energy and Environment – EENVIRO 2022, Bucharest (Romania)

Date
October 16th to 20th, 2022

CNCS - UEFISCDI, project number 583PED financial support is acknowleged