Novel technology for implants manufacturing from 3D printable reinforced composite filaments for guided bone regeneration
contract number 583PED/2022

Compared to the limited market of products destined for bone reconstructive surgery and the high-patient-risks of current approaches, this project is a necessity to solve the absence of 3D products with optimal geometry, internal architecture and mechanical properties for customized compatibility with natural bone and a rapid repair of defects with variable dimensions. The overall goal of the project is to develop and promote a new reproducible and sustainable manufacturing technology for the products fabrication by 3D printing, using as platform the previously implemented technology for the synthesis of hydroxyapatite derived from bovine bone biogenic resources and the project team`s experience in the field. Composite filaments with printable features will be obtained based on natural hydroxyapatite and two polymers, one of which will be of natural origin. Also, superior and adaptable mechanical characteristics will be ensured by reinforcing the ceramic matrix with multi-layer graphene-based materials. Further, the filaments will be used for 3D printing of products with regular and random internal architecture (based on a new STL file developed within the project). Afterwards, the products will be tested as to evaluate their performance as potential bone replacements. In this regard, a patent application will be filed. The proposed topic is new and challenging for the project team, but all the premises are fulfilled through the team`s synergy and previous research experience. The concept and experimental testing of the possibility of embedding naturally derived ceramic particles into a polymer matrix of natural origin were also demonstrated and reported by the team members as viable for achieving the project objectives.

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Development and implementation of a new, sustainable and reproducible technology for manufacturing biocompatible 3D printed composite products with modelled architectural and mechanical characteristics.


The development of studies and analyzes on bone augmentation materials used in reconstructive surgery, on biomaterials from natural origin and on technologies used for processing of custom biomimetic implants.


Complex characterization of the obtained composite materials.


    An ideal 3D structure for skeletal repair should mimic the biological, architectural, compositional and mechanical properties of the host bone for a proper functionalization


    Well-defined porous architecture of the 3D products will be attained by 3D printing (FDM/FFF) of the obtained green composite polymeric (PLA and/or ABS)/natural HA filaments, according to predefined and random models


    Bio-functionalization of a natural resource as an eco-friendly, cost-efficient and sustainable alternative for the HA synthesis due to its geographically widespread as bovine bone.


    An advantageous compromise of the inter-dependent macroporosity, microporosity and mechanical features necessary to ensure a good in vivo functioning

Estimated results

Optimized technology for the fabrication of biomimetic 3D structures / products by 3D printing based on composite materials.