Results

BioImMs

RESULTS



RESULT INDICATORs


ARTICLES

5 published Journal research articles (proposed by contract -2-)
- Applied Surface Science, 2018 - ISI Indexed - IF 4,439 (Q1)
- Materials, 2018 - ISI Indexed - IF 2,467 (Q2)
- Vacuum, 2017 - ISI Indexed - IF - 2,067 (Q2)
- ACS Omega, 2018 - ISI Indexed
- Sci. Bull. of University Politehnica of Bucharest - Series B, 2018 - ISI Indexed

BOOK CAPTERS

- 1 published Book chapter - Ed. InThech, 2018 (proposed by contract -0-)
- 1 accepted Book chapter - Ed. Wiley, 2018 (proposed by contract -0-)

CONFERENCE PAPERS

- 1 invited paper - International conference, 2018
- 1 oral presentation - International conference, 2018
- 6 poster presentations - International conference, 2018


RESULTS 2018


- Computerized design, synthesis and preparation of samples for investigation
- MTT assay of macrophage viability and proliferation

ACTIVITIES 2018

- Computerized design, synthesis and preparation of samples for investigation
- MTT assay of macrophage viability and proliferation
- Cell attachment and morphological features of the macrophages through fluorescent visualization of cytoskeleton actin filaments after phalloidin staining
- Expression of pro-inflammatory cytokines
- Determination of murine macrofage activity by production of nitric oxide
- Selection of the optimal synthesis route and advantageous materials used in bone regeneration applications
- Development of a laboratory work precedure for the manufacturing of experimental models
- Dissemination of results

RESULTS 2017

- Optimal, experimental synthesis parameters of biogenic hydroxyapatite
- Experimental determination of mechanical properties and in vitro behavior


ACTIVITIES 2017

- Synthesis of apatitic biomaterials
- Complex characterization for each precursor - end product phase
- Evaluation of the in vitro biocompatibility by carrying out indirect cytotoxicity tests according to ISO 10993-5/2009 standard
- Synthesis of the homogeneous biphasic mixture
- Synthesis of 3D samples for mechanical characteristics assessment
- Preparation of test samples and mechanical testing
- Complex characterization of the obtained structures
- Advanced in vitro analysis of pre-osteoblast response to HAP-based biomaterials
- Dissemination of results by conference attendance. One article publication

Articles

Journal research article - ISI Indexed - IF 4,439
Applied Surface Science, 2018
Influence of the modulated two-step synthesis of biogenic hydroxyapatite on biomimetic products’ surface

Authors
F. Miculescu, et.al.

DOI https://doi.org/10.1016/j.apsusc.2017.07.144

Journal research article - ISI Indexed - IF 2,467
Materials, 2018
Osteoblast Cell Response to Naturally Derived Calcium Phosphate-Based Materials

Authors
V. Mitran, R. Ion, F. Miculescu, et.al.

DOI https://doi.org/10.3390/ma110710975

Journal research article - ISI Indexed - IF 1,53
Vacuum, 2017
Synthesis and characterization of cellulose acetate-hydroxyapatite micro and nano composites membranes for water purification and biomedical applications

Authors
A.M. Pandele, F.E. Comanici, C.A. Carp, F. Miculescu, S.I. Voicu, V.K. Thakur, B.C. Serban

DOI http://dx.doi.org/10.1016/j.vacuum.2017.05.008

Journal research article - ISI Indexed
ACS Omega, 2018
Synthesis and Characterization of Jellified Composites from Bovine Bone-Derived Hydroxyapatite and Starch as Precursors for Robocasting

Authors
F. Miculescu, et.al.

DOI https://doi.org/10.1021/acsomega.7b01855

Journal research article - ISI Indexed
UPB Sci. Bul. Series B, 2018
Comprehensive non-destructive testing of metallic implants for orthopedic applications

Authors
C. Luta, M. Soare, A.C. Mocanu, A. Maidaniuc, A. Ernuteanu, F. Miculescu

DOI ...


Book Chapters

in BOOK TITLE:
Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applicationsand Its Technological Facets,
Chapter 6
Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Authors
Florin Miculescu, Aura-Catalina Mocanu, Andreea Maidaniuc, Catalina-Andreea Dascalu, Marian Miculescu, Stefan Ioan Voicu and Robert-Catalin Ciocoiu

ISBN: 978-953-51-3805-1
DOI http://dx.doi.org/10.5772/intechopen.68820

in BOOK TITLE:
Bioceramics and biocomposites: from experiment to clinical use
Chapter 7
Bioceramics derived from marble and sea shells as potential bone substitution materials,

Authors
F. Miculescu, A.C. Mocanu, G.E. Stan, A. Maidaniuc, M. Miculescu, S.I. Voicu, I. Antoniac

ISBN-10:1119049342
Capitol acceptat spre publicare


Invited paper

Sustainable use of biogenic resources for developing CaP ceramics and microcomposites with tunable bulk and surface characteristics,

Author
Florin Miculescu

Presented at the
International Seminar on Biomaterials and Regenerative Medicine BioReMed 2017, Timisoara, Romania

Invited chairman

Chairman at the 28th Annual Conference of the European Society for Biomaterials (ESB),
Athens 4 - 8 September 2017,
Friday, September 8, Natural Bone Session, MC2 Hall

Conferences presentations

Presented at the
36th Annual Scientific Session of the Romanian Society for Cell Biology and the
10th National Congress with International Participation, 6-9 iunie, Craiova, Romania

Biocompatibility assessment and osteoblast response to seashell and marble derived hydroxyapatite

Authors
V. Mitran, R. Ion, M. Miculescu, M.G. Necula, F. Miculescu, A. Cimpean
Bulletin of Romanian Society for Cell Biology, 46, 2018, pp. 85, ISSN:1584-5532; ISSN-L:1584-5532.

In vitro macrophage behavior on materials based on biogenic calcium phosphates

Authors
2. V. Mitran, R. Ion, M.G. Necula, T. Butte, F. Miculescu, A. Cimpean
Bulletin of Romanian Society for Cell Biology, 46, 2018, pp. 89, ISSN:1584-5532; ISSN-L:1584-5532.

Presented at the
Scientific Conference of Doctoral Schools, Galati, Romania, 7-8 Iunie 2018

Progressive conversion of marine and terrestrial bioresources into biomimetic calcium phosphates

Authors
A.C. Mocanu, A. Maidaniuc, , C.A. Dascalu, T. Butte, M. Miculescu, S.I. Voicu, F. Miculescu



Conferences poster presentations

Presented at the
28th Annual Conference of the European Society for Biomaterials (ESB) in Athens (Greece) 4 - 8 September 2017



Presented at the
10th International Conference on Materials Science & Engineering – BraMat 2017, Brasov (Romania)


Presented at the
International Seminar on Biomaterials and Regenerative Medicine BioReMed 2017, Timisoara, Romania



Presented at the
Scientific Conference of Doctoral Schools, Galati, Romania, 7-8 Iunie 2018